Evaluation of Gasometric Behavior of Transfused Fetuses in Alloimmunized Pregnant Women According to the Concentration of Circulating Adult Hemoglobin: (IGWHC)-Lupine Publishers



Introduction: Perinatal hemolytic disease occurs due to the passage of antibodies from maternal to fetal circulation through the placenta; this leads to fetal erythrocytes hemolysis and death (in extreme cases). Regarding the treatment by intrauterine transfusion, little is known about the effect of the concentration of transfused adult red blood cells on the hemodynamics and gas exchanges in the fetal blood.
Objective: to compare the gasometric values between fetuses with gradual elevation of adult hemoglobin (HbA) concentration after intrauterine transfusion and anemic fetuses with only fetal hemoglobin (HbF).
Methods: a longitudinal observational study was carried out from 1998 to 2015 with 365 transfusions performed on 143 fetuses. The HbF concentration was determined by the Kleihauer-Betke test and pH, pCO2, pO2, SatO2, HCO3 and BE values were obtained from umbilical cord venous blood. The cases were ordered according to the deficit of Hb concentration in comparison with normality curve given for each gestational age.
Results: the gradual substitution of fetal by adult red blood cells did not significantly influenced the gasometric parameters for both Hb deficit lower than 5 g/dL [pH (p=0.958), pCO2 (p=0.400), pO2 (p=0.493), SatO2 (p=0.698), HCO3 (p=0.495) and BE (p=0.522)] and higher than 5 g/dL [pH (p=0.601), pCO2 (p=0.065), pO2 (p=0.770), SatO2 (p=0.096), HCO3 (p=0.096) and BE (p=0.525)].
Conclusions: Due to the existence of a hematological system with great capacity of metabolic balance, no associations between gasometric parameters and the percentage of HbF replacement were observed; this, regardless the degree of anemia resulted from Hb deficit.


For more Lupine Publishers Open Access Journals Please visit our website: http://www.lupinepublishers.com/

For more Healthcare Open Access Journal articles Please Click Here: https://www.lupinepublishers.com/gynecology-women-health-journal/

Comments

Post a Comment

Popular posts from this blog

What is the role of Editors in Lupine Publishers?

Editor Guidelines The main epigram of Lupine Publishers is to spread scientific knowledge globally by publishing quality articles in their open access journals . The credibility of published articles completely depends on the effective peer review process ; Hence, editors are the chief support for Lupine Publishers . The Editorial board members of Lupine are responsible to make it as quality manuscript publisher which are received from authors on various subject areas. Roles and Responsibilities: Actively look for the views of associate editors, authors, readers, reviewers and editorial board members about ways of improving their journal's content. Reputation of our group is enhanced by the presence of eminent editors. They also must endeavor to set higher standards for the journal whenever possible. Sustain initiatives to educate researchers and young scholars about publication policies and ethics. Editorial board members are most welcome to give their valuable ...
Read more

Journal of Obstetrics and Gynaecology-Lupine Publishers

Image
Is Loose Lower Wear Good for Sperm? by Rahul Hajare in IGWHC in Lupine Publishers . It has super important sperm and quality of sperm has critical windows into overall health and production of generation. Researcher wants to express this research to the people living with a healthy sperm counts life. Healthy sperm healthy generation. Number of male infertility treatments has available. It has many perceptions for infertility in men, women. In India 15 percent of couples are infertile. It had unconditional hormonal secretion has not capable to conceive a child even though they have had frequent, unprotected sexual intercourse for a year or longer. In up to half of these couples, male infertility plays a role. Overexposure to certain environmental elements such as heat, toxins and dried chemicals can reduce sperm production or sperm function. Industrial chemicals and sperm count have many reported researches underwent in globally. Extended exposure to benzenes, toluene, ...
Read more

Journal of Obstetrics and Gynaecology-Lupine Publishers

Image
Intrauterine Contraceptive Device, Simple Yet Still ADilemma by Myat San Yi in IGWHC in Lupine Publishers. Intrauterine contraceptive device (IUCD) is one of the contraceptive methods and its efficacy is as high as 90% [1]. Increasing use of this device has led to an increase in its related complications. These complications include infection (1%), uterine perforation (0.1%), expulsion of device (5%), failure to prevent pregnancy as well as ectopic pregnancy (0.5-1%), menstrual problems like menorrhagia or dysmenorrhea, migration into the pelvis cavity(misplacements) (5%) and the frequent clinical problem is the lost tail or loss of the filament at the external cervical os [2]. There were so many studies about IUCD and its sequelae. The commonest and most attractive area is misplacement or migration and loss of IUCD thread. Clinicians from all over the world proved that hysteroscope is the best option to find the lost device in the uterine cavity. https://lupinepublishers...
Read more